ࡱ> CRoot EntryI?@AB !"#$%&'()*+,-./0123456789:;<=>?@ABCEFGHIJLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnoprstHwpSummaryInformation.DBinData(:k(:kPrvImage PrvTextBIN0001.binSection0!4C< ij ̸><><><><><><><><><><><><x Hot-Line &><><><><ˆ: 388-6522, X}ň: 388-6523><><><><><><> <0><2010D 10 14|><ij>< 2010D 10 14| 12:000><> <><X}ňHm X}ňH(& 02-3156-8031)><>< @ ><4>< @ > <><TĬ}ň(& 02-380-1709)><>< ><l><  $> <> <D̹X̸(€|) ,  Œ - XǬ ), X֐ \ -> % ˆX}ňHȭ(̥ xM)@ Y}ŬXƌ 8(10.13)D p D̹X̸x €| t \ͅ    Œ pX| \ . % tǔ m ɜ 7  H| T*X, xm X \ p t H1 pX D |XǤ\ Xt,  | ȈX €|D x m ` 10.9 m FDAX  )$     | ©h 0x ֍pXt. ; H Tִ: D̹0x X֐ ), $ƨư$X}ň  ; : 7.20|ǐ ij̸ % m FDA `Ҭ Ȝ\ SCOUT *@ `Ҭ Ȝ\ €|(m Ȉԅ: TD) D DT¤0 \ ȵ(REMS*)D i \ , ٳ ȈD h 0x u1t 1D ^  JŔ䲔 ǥD , t| `Ҭ ©\ t * SCOUT(Sibutramine Cardiovascular Outcome Trial) : €| Ĭ ƥ(EUX pt 0| `Ҭ  03 -  09 ) * REMS ; Risk Evaluation & Mitigation Strategy -  DTȵ %GIF89atɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!,t H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ k 4%

Yf< mڶ ۖ'WڹaI@"p¹xu(nc !S oEK(h&x AlB pE-Vr5oRI!_\,bDZpyD/jW] p׀LH&L] F)e6&FZbؖXvTTx:PguiIV.7#r72Ko©Zvo)+5i衈.iQ&`A FI)oBhR*&ea:i>ꪓJJji饍ꮼ+창J&l.lV촽e+ߺ8kVl{n- Jڢ[nK+z 7̫EF,ĄVlg!ny֙"s g##阝r蛋81mCqz&>%m#@C)q+% )&,&*vms2m2ÌcmߌrSe]ZVYwOrx'׀ݐG.և z׳kfSN _Zm=d-9[޷۾=ʸk_e~.h_MŏcCOrgsR/n#gwByZr9O{+Y@\m!jලmSnA> ~: à-8l au; L3uMs8)݇5s]hL A'=| 3ӝ@tp %x̣J퍂*GML"F:2'͚=^R/\ӵzp#">ei* 72etK#翷1Oo I2L۔gj4$c7; :0D$&-̘Ij5D&͸41ʙ7f^<ۋ9FYFN&e͂zFLgFUJdG3u!2QĦyW5Ҡgb(qfFY@R'#]EIwv@ jA)6NLC:} TIa*O|r@—`e)NFNvҦ6-jSUz9 xͫHW#A+X%_Wd'Kʖ$ ;,b7 <(`a``a`0U hx $ 0 <H 1002010D 3 5| | $ 5:42:38}ŭ5, 7, 6, 3018 6@\?@o;׎\-އV?T I$ vmV%h*$.*x@1&tB~qR Tm@`Ιٙk+)jw~s9ߜ9{@HVhF>;UWI{b8^^%y-xUY` apS"I Gu.,-a? ^p p 1xcO9ccp7(;G0??겲;Fasi>{sv+_cr14h.}'?Jr ƍFADǭ?[n"B&>|$NQSy\HvYQRC~d 6&r[av_bY >1eÛgAIR7 8~!XRgsl)G#HLqOr?> 3_UiEO $x~?N\k Vn\" vIѬaI=oKnV?ߤMfMڻ‘TPq3*ԽUuF/7CDIUgN?Nc? O(on-X~{kkF9FXc=6=fꑴ6NOv>s*c^yW<߾xyc/L㏌WUH2zRT7R|fPz~^ʋ[1U}}p,]֩?N\6=v{<4g^Džwc0? sAE1Cc~V{xkz}isv^Szg?="nG_Gd}򼍇3bғNA;+B|_O|ZHm8ǩeO=<,ByՕ?yz\1iA \iϡu뉄[q}(w>חQYl^ב=tiOtVoPݛ6֩td:6c?jV<Ūk^#on^A1gsQ=j7qo}xc_ub2^㒱;?:V$^q yʯ\Ѥ{˃B;KzSѡk;w%HON>Qv?eI =(7"F\vm9U:*RV|FyY.7֝y=)O,u7}'BntT!V5'ųNTVBߪ>QQ/mwͯfttZ ʃ^>>>/yrSݲm' waifp&40pUN|ncAo/ `?"F@Pe2x 8 SI1wVY13`*+l?r ۀ PvXevTe)>v@ʺ$>{|qaJ' OpoBOtP( 7pc8Rem4V.$Fa:,MR% ~1]1}d; bq,nڥ7v*< S`6NDu= U ^ K*yϊ|K>%&;~謰l0/\,h0C3؏HWP Document FileQ l ;[1/+ G$cO>}cH[}30V1Z1,b y`-gU/U:<gUx<y4[Tj(梴jR(pJQ5ϡ!Z=-b*EMu*I 1C]u~^gØd~;Y\XY!,lKKT@L..&"**!,'!$%**yNEuuu߇ٹ8TϊUc\7`$_8XN y 0`&f0 3Iv>멛w ! Yo٤:a#i5DvӂB"2r5.iji\1jjvmG'gϻ^>|GDF!c&$ k42D@l'Vhk7ξڌ?g!OR*ѓ}D ¾ dѼx:[ y CR[n,盩6R,6hT:q5g+ :jޥXlTv aicBffO>mY'ښA~5a{>3ἢ8r)BP c}\foE$z}֍EX8`x5NqlN\~#h1lcId4Yߡ:>&.OyگIieW˦mB } 4`eBP,oa6^U+:d[}$y0A%SQ)6a}l0Jo=|PswJq(۹*]WU{7ap1/۝R#*oWAMH󏎟4D/VNMuIUDrIȎ,IbJTee8.3Trp}} rsT v{#_e#pJQesz!nry|HuF6%٦[Uciuʷ jlc/|~/&H-ѱ.pš.ȂcNJ#;z x{M., D]YS?>3<geP s7 9%*֣U<:X[J7/wV/?0q=C+u: ވt׽\RmBih^xJom8ɾn5N;4&ciEz"ӻ nmk̃L_v 5hKC_Iz}6讙Ѣ}eȚnUoMo߷/>r>T8[z[r \KlxJt(l-~w_d"kl+r#,7 )%T0Nf!KJf{}{c #oN,rlp\ؗk#4Ch<-\+Wܑ?SdCm G8tp> +5 fIBW?wm}-2h!xc|_bA6b1E:9f99ȳ)mYtv{(ku3eTۜ'W[Zoіj!Gc ɝN 1~?tȤhWr+g`q J-!j5g2lj4"JB}K׳.2kS7V$\Z>9X䘱ľ0@C谕K{Ƶ,b!Si"YnD,<߮L~P[f)9 VpV׆dWVolr%@SxhBQ 7]#&/ǷchX&Xz.6C?sMwAmӁb3Nt4ܩ30EykS-/eA^=1LL!$XPӈ)w? wJw6Z9qKKMH**}oSH/lw$ؗ>Rh߼@yڮF"SV cANy[ӑm57Qff:|X.N ]U knO8Uł诺;5~Y UZW. քyy@0I_FQοCq-gE/&c,iX[=[¶D|uǓvnp'S1wR1j5@E@t Ż -7`%NgQx؂5O"#]?Y ib@?=T>>KX7y]9+=.G08KE,2~źNN+>Mpgg=[M/1% ]*sГou0'%IdͶ.²y_˯.MzRBAw:" 2Yū ia4w1z(rg HJ WfwX}o[R 6ak[:Dowz4Ԟ8BFrys_KG $\%Ĥh/rJwi<-f6h^JO4=5H3䥖U9T,M}KȘݲvz n%1\q LQTИ/o.Z p$vc8ҺBb, +^aTܒӻ,= ׾/LmZC'Y.RdZkl>X$sߝl\ zcs@ 1Mû+770-ťSCn~M5e(d>|3YEka{ C)Gs6'Sd j5yUGRn汤M8p}Xr"qI6}쎪ztG@Al[Ymn3V4|cH/.ݱN %shx&Z 0o=Kȡj}tJ:Q6h 2^|W=#Mu3 WDs{-o4& ۅ0bڴ|Pyvްb&mو_^Ʉ'~%JdK]Z$]b{lzkPvV 7JʌI\|tAV>̹½dw#0.znl /}N3\.U86ձ<4CBL6Q~21d TV:`wuM&]DT؆zws^{Yq&f7K infe/mhI0`;Wk+w'5_Ggim&s)9$V7[֞)X.-mm݉ ǥVx\F=Ws[%q @ZƺZiVaIVcK?=%9lvyJ%}- Xzޘ4!Yۇ)%?t6?R!}VX,aԥgbVGuWu^qrw⻿MyvvEo,R YdRp>Qͅ 9)a $as߷tJ&EgyInȐ?/@s8Y&2|`a.oU儰>Xԍg$+~gg,C輱iAqinc@i-FY:OswUUD$߻sZò%&ԥvחç E) ;ުG㞾$E#Y)bz䊍6Y$M>䐂Щ,GLs@?ώ|,u}ʼ2#'=4"RH-~qy$%+pcL:׫ekp[C+(—1Lecv2}(`]iOZ4sHF34iU$ "zj2:׀4'S=mDW y0z}Wt˝>م1y7i6MaRs΋ex{N)\lq,x<:".XFYB7yWaV Ŷi461V*͸$xU}/O6Icl~#wNVK_5[ոkkHqq7rq֣=ڬ/fڹac E[CU /Scm +pF0DKۧjci:kGYHS {P'9bD G2U-|]w?M,)# x+*[*<=9W6bel ĤtAO663Lm`2sx'My%m5.ȼȤeYB'+p:)tψ"Y-#:x57ϑ$ 6.45ahFh"aA #ЌT`~F9n(BW pTU>Ao4d@L Qag1;TYnw8.3nƤ L:jf-E+=݉޻{=;9L)2~<{D@|bsW~On~">VwIoSSIPF4?TGіQ"l E*x- PVa)&}ʷ"g<2zQmOna\{zf`q=4baOtgp~+#Op('u C< * yB"Tw[(a /,-~;+ ]Tyk i 7),Kzx"N+(@ȔVSvLi'Ǚ7Ѡ1mm?:gX70#WP'|t ,Rקȝa"=LpVeϵ{.\r_*J˞k#zl~# ; gRO3{ܽtf*DoZ.M/UUmYrw'NPrGOoKF\: f& ?m~idzVc@So\Nm+\x"De6c,(zbC46O&hVqr-y NS.~7=t{+xཁ q%?2yo}rg˹жq]4uRABIOCMCq^T ^KBؕ5ZVu[áع)UYe I!ᎿMIf8TV C !ڎ f|6Ul`4:N'3{ZvYhk vܡW;BlxJuJ ib,o,2ǶFUWv}wcd{:'Fh1TݿnhĈ[׏$W0NţøS"Y 58`@CZ7]Q)'E"P:bꡝZ.j!أL]ȋNlq4yp2HjpCDr?rBWroBsc"\cM_ŨRq3 q)DI3[YFMKq|(EW(U'P+r[TQ?]" Q6bQ8Jahq?FN1ebܣV $r/h8qt z'wE}jC0RyS|F]:eTvȽR)w YY'gCxE[uscfG=l5[ ^&zKA\7O}QdB?ؾĬ~RVpe:Eq7O5jM Qfu sgijPBg8+9~zhW EUY`YQ`D==mx}Xncw|!P$RVF^nLx[A˽JS(ayhR<>bcr!G.D{L1m^&9­ǁ"UG9I=* * "h{WXt1^6Yf}s)F$+Ria\7}1oTybѭQ+|!ޮ}¢cTq"WTbf [$؀'{V}aJWS&2=[1;qV%4\Fe؍J.a@QO6lkvks͹^30^زg^\e6Fb']kFbGJQ,UРf  X{OqN5(86cfwcfwpΏff[Jok 8L>FpۆlA ^ *-@(} v1_N&a}u+>?rϡ|M9?Ô 񌽇N+#~j9g2X4RAfdb"t]KGKe=ůyԟtPоo?lT$/w^MrP\A1)orQ>bDG]1[HRbˁHߦl;~K?'s/f)DIpM#ffsUK>kjlG>R慆o ^9fƒ[J9F{aQOŝho~fb%s-D뢾_-=G,=ςs*Gs=SA|L)9'#rJ9܂K]3` dV^ R;,3͛65oލLY' sbM`Gf1\o ݜ`DBv\X0u/NEߊuW{ɶS_e*&"45S~fV~]cb(5}OF߆>wE{ͬ̐5{ɑJBN$:'?G+u2T˯9g F[S)v: -`{޺.&ACl΍S44䯹>sj΢Wc!Hſ"?0>=3'Yj ?CX3>U?슑|O|ڜM*NFN:\6+s¹'JU'KV'vp5Y{ц`1Y:"F0=캸/Ψ}X!\>i2Z }Ƒ}'tc s=n\݈[Z,#Qv~mXUt1O~ӳE}7sv{nUaΥ9?_w}v=pG=9Kf]6 tΘMI4n#1qdo'iUה<+Be&ڬhҶXډHw<]Dj[q9w=m!7*ڏ9=3 U|Scr#s|bqRQ<˅bVݾ?{/~hFwuX n$U}젷+AO\Z{ʟ(?Dv'.$2T!UuKԎwwη{L,X,Wh;/ᑒs U>?Ts9R:!+Z؎&m葉6wh}׏v18aG5aء F-[ѭѥNJ姘 T>iMw#NrpUnJl \x¥> r+őQA~=%]z`wq@UTUq;.54 -U6. QF+2íA`azƊYxuYkKFȯu}>+pי8 R_a.f]Vy(PN7opy6}7ބsʨbsƃbYΊj"jSH "HJClk{ S4Ht C \HlHM-z'kZL[TԢ:ɯżakK{b-ؓ_֢<#Ң!C bXE R{kpZ\ \',ZlLb'Eu-%2kƺ:_쬥HgI@ee2YZtΚzu +( se1uНԁ3]3%&X,p[Ztޚz9OLdKvz3$Փ[9c,=s#&z̅ Q1K^TOn=B9p_Z'c;~`l&17񶉔R"9 ji YQPTX)RulSC4<`oʪ*J79\y:Rgtaͽw=kb<PoR]Θ9\bԡd;>.cQ8@y 1o;w8<4xgK\ol1Ӏ:OQR7z y; AFa ]vgجبcR$oa|^;룾d6ޞ83Hw:K;6|d3=T0Aw~hBk{ݨO{.L]G5ugƿj$=##jlOmb>q}u+8Kh|j qs[{ǞTdq7JNMcxi|7܍'#gM)g7,{bxn ZHSW9>Ϣ-ք؇q_'|0ʴ/lEұ|W"A=8L;݃Wf73Z<'}F>n:Xzc:\&z5uj*ݗXnB@&k}#s|7lDq=t|{{>0nvs_/vsPr]|nwf;O .HxR??k!zʌ./ri,0Q:YFfvy6+8[, S Ԕ J{̉AAT蓑S1NKOHuF*l'itWALN`. p1x^lP{Úh'5{+@gd:Vъ#?\.Ly1__AH=$)QUrk^T.)Q|H:2HiqUzVWG(-p\^^<- Wf4gkMcljpV Xy/Uwf}W^-8E+e7)z_'##9 K]+TqG^!qx$}aj*JOL?:pxBNǑ٥)U7 2~{RysQޗ{~{IݢB_8oS*~{S9S2s8Is2gj+}7wߥ_亐Uҗg;Fu:/‹YYkZk1#:_ٳX~Mo|0L+OBbD3S?S.5-N wd./O1?1HnmS'To"rC(rQcBlٸBQs *(sC~gp6ܒNE-lĎ%X]85$=Hlrܽqa2>O b|9nY]i?ؿ4G+\3^kO5qZ'0gƃdju t.ދerW/ k9uMB2RqΕW{H"}57S%t~RK2@2`|ËJlyb_p٥mAWuw1 9V ]X>էy 3K?nܙv~8m]/ x)|//Y xN"W]!=c\1gBe\F^zmKt(N+/8`a^[! 1 :jhڷt?XrD`ơ H:Uy<$ SV &R(mO':>~܇u \0abb"UX#G=ɳzaZZ&Z 919;DL7%-jXujOEMejjP;I +S0oʠ3M 4bak"3hq OdozկQV`GDUd;>7Ƈ4Bm^j#p(Wu=zMgR*'^˨S,gcNfV 88 DHG" idRlz)N Ĭl9+L+7Azˤ4H!wV &eikP'#r2 +f"KuK͟ޛ#-(^IbXM~I Gr59nuY+NV2%P;I +SS@Ɍ׭q;^A5:|C4=z''?:) $!Nw4b֩U:smpSjj)ܰ'abnv\flms8DNg3 ŦkxbV+gUp.3+#`F ;IvX}vZ@*j;lS+V$;@VQQ 鉩 t9yYR[G;Ffguf Z R?(,mKzEV =: 8ZPO #Ws7}XNT t5ZgfgN+/3RaN2 3shak6i +Œ'y&YعɟgXM.J׻HPE2.ɩG˺wwDNffF)')abJJE(Ejš!mrX !IBX !]lnxp>};SS R}ygutRB3\~Rnj8$V$5@LN53Y#5.qt3HWH[;}[ gㅅdiߒxGmdRaNfV 6;S?i%kr!)ܰ'abn05]4AX=jXڠ1P $6J0O{x{B+Y 'f'R8aNr ĜlpɓW&*e<b ZX5Z:riy-5RhaN w_!b#- -3Nɴw:^5A G 5 cݥ}ӷQXa9ɫRS^҃ɭcOQ 7InX27 ya}UA{miu-VeޒK6(9,V$%@L%1u\X?qhTJ7S̍N= uޔqZ^S޸e) )g&T#?u,VO ?I~X"נ*#GNe[&E㓿V:13x(z&ԝ22>T8I +jʣW'Wհ*+745F 'INXmkTGD(5rtK^X1/y\-N(! b N 1IbXb+Q%Z!3] ^ 1IbXb21pm b #f @LAUô')4Ah02sy 'ٙNI^t7Raq p3ō:|9tm[$g~[#nR$P lteyd4^U86|E4hM]m+Cۯ*I@rXGD}Sx/3f=u.9?z u BQՖ3OvozY36?d{_O'f}V$Rc^X+s}uakZTK!8I +E`R#Qw8[T#fڡ<\g)'YabVVqh@hit|\SnI6Sf4JM99yב-WM7RaVK`V`#M4þkp_PL61*1~~4,I!8I +K̡U#bmS/V`OLRFabbv J$60] \_X2Q5ꓖjOܛ$e6j+p!V fh`gbY 5AX=XZ#6jB+p V &h{H $S]tbp6.Z+9ߖ瓟Aa)'av!=u[uzXڠEz汽z+0_pWΏzXѓ,@bDOB Ġ5}AKWH[k7\8= W8jR~p!qGq([ =F]7u< -s)s+s/0ge+φxeuuϯ>hP>kp?zXQ$, pC4ϤP #ܘΣ.M)ԃ"boֲ-ZbxSi-O<ϣ/-cx/_?gJn򭂧WIdb̙(W|oOEORXXؓ܏sMǷܺ>AJBO0AETg|)y5t:Yi]S':485Q B2*2V\HȕzFA''KP}?SYpy7IdH|?5Ab3慞_$4rOy 3߉cށQho847D䇽@L<^^=m\ɡ:3) ek"'T(EՄFII@K3nNEl@ݜATAjNL?*;r:\* ƠΦ~)Wl;tw}~{KǬVKao X9*g֥ :}_-Lk'E }AX#1+4:rUa<6_O8f#8qz3\i&soobiΏUCAB)D}f/em}O骶>;;W 0E\cFTCzZ_NaJo BΘǭ8g636t=7EĠ8Gc=( 37 m{a:#jR^Ejt4HA;X~eeOv=p.)`b$ϸf4 ֗ i(]η[k\ s .im4ޙoV^-DTbVԦ.,&*Ǥ'-Fm.^߬w^ޟA ^T- v0avSC(B({FNۥl~Cp|g`|yՖ.d"ꮰ!Fkq?B 0T5ݭJ1B2ڭg3ًŤѱ+cҳ%I9RI8G?(b/̍o9_#/_|+0*u^ЭWʺ*NvUx}dl&i!z͌&ݣ+ SYDܝrO 3N:J8:/`34x O}XS 5F>m[/Hϔh0~׭MCڄq~ׇ ^ CtG=|rCw֦N|jJh :}"2AMC# j`qpZy)ftѥE ϛ]3"A$+3gu;-4VNs"M_!=42NzCwtp ~ [X =V8ia"x5z6j };Ķ oI?4 v ~}fREwjoNNW"Աk=nuB%8K[GSԝ}#UOsc+#uGެ<J\WH5?) 0Jy@t.95݃!'kVQg!`7u"*euđ eĽfFx57}z"f-&h.,??}-w+!Jxt7m,)lXnSOn'e/Dr&"A:V؁˄ cLb&[uRDNc5 ckű}T¶*D_ykſJ 9hg*JfZ\ܸ9 -`l@Ď]Yo[3Az=wqf.oлfJB&VYmE@X+dơ5;{TQ&)nY]ӱJ_J1&bV] hS֑xܨR1Lo{LQTHt Ù<؉{2_U5NZR 4+2Mxsɨ+7\8KD)Ğ畭B:GD gOS>)})!% TMT|t(5V@wϭ_\i dsg6JLC͘FlKI /äk}%RU&3rQ];.'mlIhyXpG!E/V\JgݽX. 2.D gV [VHBs Ѣqpl_`S4}őul]O""C4PY=ᭋQۣf; yChܳ]mah"S/XχZtrG@?6t T *V| Zڳ#PMao?>g!]yP*܅ogo":^d"4<7G#H/δ[ nڷb`C)қi͹s%O$+hw(O;#e: @QYtqAZw,޵sm(lAq~=;tЬ7C#t8=;AP-o%]L A:.Ì]a(wpJ;= H6:6al'2%c@F_8k3ӉJsDeX6y-drwuiًWgLO#g11u E(]b ݁ #W>KAF;)WKC[a嬫(d Q`sqbLA}`x:m΄8wЉ4vydh&3*Q52+<-,ivyo_?@ghWõCVd~J\v>;؉ 3uD^}7QoǮčayV8t<^Bq={:j'&i6Pl6Y׃EOՌ5'EP&tYZU^p}z0Gy@HPjOn]ɽC4w=e+=6_h:Н\dD rv@ )aهv}cϹlLȏiW/=9T%*Pc7mWj>_oQ/Ùɴ@`8BLGt.!mc*޶e۲ߵuR3o{FؐȆEE=nS}쳤;]1GU2߹#smQ"h)ɟ}2:_9U#:|Áh_"V4:/w7; Ԡ~mU5=5UQY96Ku<6o+ SGͶtvPX bWDUa;ShO a+",Wl= 7aq Qnv(T8:9* 9__b[vWXajA ?،#Z/R%7) ߾{o>f£_*bmg:QFs!Jޗ;E`n$q^.Ηkл[PU+y0Ȇ 2¤5P[l=,k[-&ETX_9 uw9j}rS^#u풷asSHq=;_Nl((̈́1KxYI.&9{k4CY1Ү(,6|qO+bZ. 1͚j2'AmGћs3QB{hȐB kl)?d,hz3`ebbkV فḽ>tD*|WyqU1OFqR"Z۴^~lՊ~:5z:UU;;93ZS:; QMuerm,ZlyQY+",vK=IwjH_ϊHZj+LM]T*x3HNo6FrR- lO n'Ezvzea%Xp(h?@ABCEFGHIJLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnoprstHwpSummaryInformation.DBinData(:k(:kPrvImage PrvTextBIN0001.binSection0U4C< ij ̸><><><><><><><><><><><><x Hot-Line &><><><><ˆ: 388-6522, X}ň: 388-6523><><><><><><> <0><2010D 10 14|><ij>< 2010D 10 14| 12:000><> <><X}ňHm X}ňH(& 02-3156-8031)><>< @ ><4>< @ > <><TĬ}ň(& 02-380-1709)><>< ><l><  $> <> <D̹X̸(€|) ,  Œ - XǬ ), X֐ \ -> % ˆX}ňHȭ(̥ xM)@ Y}ŬXƌ 8(10.13)D p D̹X̸x €| t \ͅ    Œ pX| \ . % tǔ m ɜ 7  H| T*X, xm X \ p t H1 pX D |XǤ\ Xt,  | ȈX €|D x m ` 10.9 m FDAX  )$     | ©h 0x ֍pXt. ; H Tִ: D̹0x X֐ ), $ƨư$X}ň  ; : 7.20|ǐ ij̸ % m FDA `Ҭ Ȝ\ SCOUT *@ `Ҭ Ȝ\ €|(m Ȉԅ: TD) D DT¤0 \ ȵ(REMS*)D i \ , ٳ ȈD h 0x u1t 1D ^  JŔ䲔 ǥD , t| `Ҭ ©\ t * SCOUT(Sibutramine Cardiovascular Outcome Trial) : €| Ĭ ƥ(EUX pt 0| `Ҭ  03 -  09 ) * REMS ; Risk Evaluation & Mitigation Strategy -  DTȵ %GIF89atɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!,t H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ k 4%

Yf< mڶ ۖ'WڹaI@"p¹xu(nc !S oEK(h&x AlB pE-Vr5oRI!_\,bDZpyD/jW] p׀LH&L] F)e6&FZbؖXvTTx:PguiIV.7#r72Ko©Zvo)+5i衈.iQ&`A FI)oBhR*&ea:i>ꪓJJji饍ꮼ+창J&l.lV촽e+ߺ8kVl{n- Jڢ[nK+z 7̫EF,ĄVlg!ny֙"s g##阝r蛋81mCqz&>%m#@C)q+% )&,&*vms2m2ÌcmߌrSe]ZVYwOrx'׀ݐG.և z׳kfSN _Zm=d-9[޷۾=ʸk_e~.h_MŏcCOrgsR/n#gwByZr9O{+Y@\m!jලmSnA> ~: à-8l au; L3uMs8)݇5s]hL A'=| 3ӝ@tp %x̣J퍂*GML"F:2'͚=^R/\ӵzp#">ei* 72etK#翷1Oo I2L۔gj4$c7; :0D$&-̘Ij5D&͸41ʙ7f^<ۋ9FYFN&e͂zFLgFUJdG3u!2QĦyW5Ҡgb(qfFY@R'#]EIwv@ jA)6NLC:} TIa*O|r@—`e)NFNvҦ6-jSUz9 xͫHW#A+X%_Wd'Kʖ$ ;,b7 <(`a``a`0U hx $ 0 <H 1002010D 3 5| | $ 5:42:38}ŭ5, 7, 6, 3018 6@\?@g;׎\-އJΏ Ԥ (M*MBU< @U7R]# چB~qJ2PA@R ;띝rfw7gΜ͙3[`:@@H VhF;UeoL^lDZEK-تuG0`8 sag$I#:zHa  H4\p \z?~/` v >:QvE# vvWO]VVtcGH5r;MQ{{*nLNܣw;<ࡥo(Panxj4Nt-χq6ch$uGPgd7u_IX /8}n? /1ؘm aT`g5Ƅw o#QcpI0,0by6Kam\j̱8 18?+N(/~)&W=3|݇8:s%(Xkq0i&mF&_Q, [X7K6i GBHSeCB^V_\SVz "*Hs uZ?mXEyy H@Ƹvm,mcd?<#l3cƪI`cg+t K z5]`avl>#~ٹH̘b؊qr x ,vQo&*!}M꽅 ϙoT%]-:|t=f3[c Y Y Y&dz(q[?G.k:.ĸۼa ֯}.?)?$Eww\;󪾟׻=?qwO=g:ʞ?$m<χnA<]eǝVklujOxjYgžsw_GzxhC9N/~j\B.$W]ǵB\Ε YHȺחr}}σe9?)ҳuQjcau^F=v{y޸/o>+I6w>1/&gzNuCAFuٳJM x%5[Auov~v[XґIHcۗۨ}^F2y_!>uQO\h5?6EziB0 H@{$1O}_ptqpޭSN1؁A{N }l:-oM?L'栿eF+Gt+ߤ-VK؛euٺҙ255wAAz8C7;u8x}]ٽ4N!ӱ<(#~O"T5dsPS[sB?}܈Fb+}1m F^gjv4CM4,0ZVL2g5KlwuDXbս^#ݼ~CcOx)#Ŷ7wRHΓ?#wZWg Dvi=(Kl[DUJ'#^}ʼnxKR[Œ<{'+rEE/~ }|,yK5{MKTO9Gzܫ|Rxt1/K^AMiw6Z'䚷&nSV2uT<\n\~6֝y=)O,u7}'LntT!V5'œNTVBߪ>QQ/mwͯfttZ ʃ^>>>˯{wSݲm' waifp&40pUNocA, `?"F@Pe2x  )(L;}QR~UY9m(TYG ǀPJ ׀ Pv\e]D|maJ' OpoB>!#@Qo-~(pL6MX- !h\.}ItVY& +K>cb 6UY\çKoU#xaɧ|>}L;};0RRX§`ny{}1XBj_x@;謰l0/\,h0C3؏HWP Document FileQ l ;[1/+ G$cO>}cH[}30V1Z1,b y`-gU/U:<gUx<W pTU>Ao4d@L Qag1;TYnw8.3nƤ L:jf-E+=݉޻{=;9L)2~<{D@|bsW~On~">VwIoSSIPF4?TGіQ"l E*x- PVa)&}ʷ"g<2zQmOna\{zf`q=4baOtgp~+#Op('u C< * yB"Tw[(a /,-~;+ ]Tyk i 7),Kzx"N+(@ȔVSvLi'Ǚ7Ѡ1mm?:gX70#WP'|t ,Rקȝa"=LpVeϵ{.\r_*J˞k#zl~# ; gRO3{ܽtf*DoZ.M/UUmYrw'NPrGOoKF\: f& ?m~idzVc@So\Nm+\x"De6c,(zbC46O&hVqr-y NS.~7=t{+xཁ q%?2yo}rg˹жq]4uRABIOCMCq^T ^KBؕ5ZVu[áع)UYe I!ᎿMIf8TV C !ڎ f|6Ul`4:N'3{ZvYhk vܡW;BlxJuJ ib,o,2ǶFUWv}wcd{:'Fh1TݿnhĈ[׏$W0NţøS"Y 58`@CZ7]Q)'E"P:bꡝZ.j!أL]ȋNlq4yp2HjpCDr?rBWroBsc"\cM_ŨRq3 q)DI3[YFMKq|(EW(U'P+r[TQ?]" Q6bQ8Jahq?FN1ebܣV $r/h8qt z'wE}jC0RyS|F]:eTvȽR)w YY'gCxE[uscfG=l5[ ^&zKA\7O}QdB?ؾĬ~RVpe:Eq7O5jM Qfu sgijPBg8+9~zhW EUY`YQ`D==mx}Xncw|!P$RVF^nLx[A˽JS(ayhR<>bcr!G.D{L1m^&9­ǁ"UG9I=* * "h{WXt1^6Yf}s)F$+Ria\7}1oTybѭQ+|!ޮ}¢cTq"WTbf [$؀'{V}aJWS&2=[1;qV%4\Fe؍J.a@QO6lkvks͹^30^زg^\e6Fb']kFbGJQ,UРf  X{OqN5(86cfwcfwpΏff[Jok 8L>FpۆlA ^ *-@(} v1_N&a}u+>?rϡ|M9?Ô 񌽇N+#~j9g2X4RAfdb"t]KGKe=ůyԟtPоo?lT$/w^MrP\A1)orQ>bDG]1[HRbˁHߦl;~K?'s/f)DIpM#ffsUK>kjlG>R慆o ^9fƒ[J9F{aQOŝho~fb%s-D뢾_-=G,=ςs*Gs=SA|L)9'#rJ9܂K]3` dV^ R;,3͛65oލLY' sbM`Gf1\o ݜ`DBv\X0u/NEߊuW{ɶS_e*&"45S~fV~]cb(5}OF߆>wE{ͬ̐5{ɑJBN$:'?G+u2T˯9g F[S)v: -`{޺.&ACl΍S44䯹>sj΢Wc!Hſ"?0>=3'Yj ?CX3>U?슑|O|ڜM*NFN:\6+s¹'JU'KV'vp5Y{ц`1Y:"F0=캸/Ψ}X!\>i2Z }Ƒ}'tc s=n\݈[Z,#Qv~mXUt1O~ӳE}7sv{nUaΥ9?_w}v=pG=9Kf]6 tΘMI4n#1qdo'iUה<+Be&ڬhҶXډHw<]Dj[q9w=m!7*ڏ9=3 U|Scr#s|bqRQ<˅bVݾ?{/~hFwuX n$U}젷+AO\Z{ʟ(?Dv'.$2T!UuKԎwwη{L,X,Wh;/ᑒs U>?Ts9R:!+Z؎&m葉6wh}׏v18aG5aء F-[ѭѥNJ姘 T>iMw#NrpUnJl \x¥> r+őQA~=%]z`wq@UTUq;.54 -U6. QF+2íA`azƊYxuYkKFȯu}>+pי8 R_a.f]Vy(PN7opy6}7ބsʨbsƃbYΊj"jSH "HJClk{ S4Ht C \HlHM-z'kZL[TԢ:ɯżakK{b-ؓ_֢<#Ң!C bXE R{kpZ\ \',ZlLb'Eu-%2kƺ:_쬥HgI@ee2YZtΚzu +( se1uНԁ3]3%&X,p[Ztޚz9OLdKvz3$Փ[9c,=s#&z̅ Q1K^TOn=B9p_Z'c;~`l&17񶉔R"9 ji YQPTX)RulSC4<`oʪ*J79\y:Rgtaͽw=kb<PoR]Θ9\bԡd;>.cQ8@y 1o;w8<4xgK\ol1Ӏ:OQR7z y; AFa ]vgجبcR$oa|^;룾d6ޞ83Hw:K;6|d3=T0Aw~hBk{ݨO{.L]G5ugƿj$=##jlOmb>q}u+8Kh|j qs[{ǞTdq7JNMcxi|7܍'#gM)g7,{bxn ZHSW9>Ϣ-ք؇q_'|0ʴ/lEұ|W"A=8L;݃Wf73Z<'}F>n:Xzc:\&z5uj*ݗXnB@&k}#s|7lDq=t|{{>0nvs_/vsPr]|nwf;O .HxR??k!zʌ./ri,0Q:YFfvy6+8[, S Ԕ J{̉AAT蓑S1NKOHuF*l'itWALN`. p1x^lP{Úh'5{+@gd:Vъ#?\.Ly1__AH=$)QUrk^T.)Q|H:2HiqUzVWG(-p\^^<- Wf4gkMcljpV Xy/Uwf}W^-8E+e7)z_'##9 K]+TqG^!qx$}aj*JOL?:pxBNǑ٥)U7 2~{RysQޗ{~{IݢB_8oS*~{S9S2s8Is2gj+}7wߥ_亐Uҗg;Fu:/‹YYkZk1#:_ٳX~Mo|0L+OBbD3S?S.5-N wd./O1?1HnmS'To"rC(rQcBlٸBQs *(sC~gp6ܒNE-lĎ%X]85$=Hlrܽqa2>O b|9nY]i?ؿ4G+\3^kO5qZ'0gƃdju t.ދerW/ k9uMB2RqΕW{H"}57S%t~RK2@2`|ËJlyb_p٥mAWuw1 9V ]X>էy 3K?nܙv~8m]/ x)|//Y xN"W]!=c\1gBe\F^zmKt(N+/8`a^[! 1 :jhڷt?XrD`ơ H:Uy<$ SV &R(mO':>~܇u \0abb"UX#G=ɳzaZZ&Z 919;DL7%-jXujOEMejjP;I +S0oʠ3M 4bak"3hq OdozկQV`GDUd;>7Ƈ4Bm^j#p(Wu=zMgR*'^˨S,gcNfV 88 DHG" idRlz)N Ĭl9+L+7Azˤ4H!wV &eikP'#r2 +f"KuK͟ޛ#-(^IbXM~I Gr59nuY+NV2%P;I +SS@Ɍ׭q;^A5:|C4=z''?:) $!Nw4b֩U:smpSjj)ܰ'abnv\flms8DNg3 ŦkxbV+gUp.3+#`F ;IvX}vZ@*j;lS+V$;@VQQ 鉩 t9yYR[G;Ffguf Z R?(,mKzEV =: 8ZPO #Ws7}XNT t5ZgfgN+/3RaN2 3shak6i +Œ'y&YعɟgXM.J׻HPE2.ɩG˺wwDNffF)')abJJE(Ejš!mrX !IBX !]lnxp>};SS R}ygutRB3\~Rnj8$V$5@LN53Y#5.qt3HWH[;}[ gㅅdiߒxGmdRaNfV 6;S?i%kr!)ܰ'abn05]4AX=jXڠ1P $6J0O{x{B+Y 'f'R8aNr ĜlpɓW&*e<b ZX5Z:riy-5RhaN w_!b#- -3Nɴw:^5A G 5 cݥ}ӷQXa9ɫRS^҃ɭcOQ 7InX27 ya}UA{miu-VeޒK6(9,V$%@L%1u\X?qhTJ7S̍N= uޔqZ^S޸e) )g&T#?u,VO ?I~X"נ*#GNe[&E㓿V:13x(z&ԝ22>T8I +jʣW'Wհ*+745F 'INXmkTGD(5rtK^X1/y\-N(! b N 1IbXb+Q%Z!3] ^ 1IbXb21pm b #f @LAUô')4Ah02sy 'ٙNI^t7Raq p3ō:|9tm[$g~[#nR$P lteyd4^U86|E4hM]m+Cۯ*I@rXGD}Sx/3f=u.9?z u BQՖ3OvozY36?d{_O'f}V$Rc^X+s}uakZTK!8I +E`R#Qw8[T#fڡ<\g)'YabVVqh@hit|\SnI6Sf4JM99yב-WM7RaVK`V`#M4þkp_PL61*1~~4,I!8I +K̡U#bmS/V`OLRFabbv J$60] \_X2Q5ꓖjOܛ$e6j+p!V fh`gbY 5AX=XZ#6jB+p V &h{H $S]tbp6.Z+9ߖ瓟Aa)'av!=u[uzXڠEz汽z+0_pWΏzXѓ,@bDOB Ġ5}AKWH[k7\8= W8jR~p!qGq([ =F]7u< -s)s+s/0ge+φxeuuϯ>hP>kp?zXQ$, pC4ϤP #ܘΣ.M)ԃ"boֲ-ZbxSi-O<ϣ/-cx/_?gJn򭂧WIdb̙(W|oOEORXXؓ܏sMǷܺ>AJBO0AETg|)y5t:Yi]S':485Q B2*2V\HȕzFA''KP}?SYpy7IdH|?5Ab3慞_$4rOy 3߉cށQho847D䇽@L<^^=m\ɡ:3) ek"'T(EՄFII@K3nNEl@ݜATAjNL?*;r:\* ƠΦ~)Wl;tw}~{KǬVKao X9*g֥ :}_-Lk'E }AX#1+4:rUa<6_O8f#8qz3\i&soobiΏUCAB)D}f/em}O骶>;;W 0E\cFTCzZ_NaJo BΘǭ8g636t=7EĠ8Gc=( 37 m{a:#jR^Ejt4HA;X~eeOv=p.)`b$ϸf4 ֗ i(]η[k\ s .im4ޙoV^-DTbVԦ.,&*Ǥ'-Fm.^߬w^ޟA ^T- v0avSC(B({FNۥl~Cp|g`|yՖ.d"ꮰ!Fkq?B 0T5ݭJ1B2ڭg3ًŤѱ+cҳ%I9RI8G?(b/̍o9_#/_|+0*u^ЭWʺ*NvUx}dl&i!z͌&ݣ+ SYDܝrO 3N:J8:/`34x O}XS 5F>m[/Hϔh0~׭MCڄq~ׇ ^ CtG=|rCw֦N|jJh :}"2AMC# j`qpZy)ftѥE ϛ]3"A$+3gu;-4VNs"M_!=42NzCwtp ~ [X =V8ia"x5z6j };Ķ oI?4 v ~}fREwjoNNW"Աk=nuB%8K[GSԝ}#UOsc+#uGެ<J\WH5?) 0Jy@t.95݃!'kVQg!`7u"*euđ eĽfFx57}z"f-&h.,??}-w+!Jxt7m,)lXnSOn'e/Dr&"A:V؁˄ cLb&[uRDNc5 ckű}T¶*D_ykſJ 9hg*JfZ\ܸ9 -`l@Ď]Yo[3Az=wqf.oлfJB&VYmE@X+dơ5;{TQ&)nY]ӱJ_J1&bV] hS֑xܨR1Lo{LQTHt Ù<؉{2_U5NZR 4+2Mxsɨ+7\8KD)Ğ畭B:GD gOS>)})!% TMT|t(5V@wϭ_\i dsg6JLC͘FlKI /äk}%RU&3rQ];.'mlIhyXpG!E/V\JgݽX. 2.D gV [VHBs Ѣqpl_`S4}őul]O""C4PY=ᭋQۣf; yChܳ]mah"S/XχZtrG@?6t T *V| Zڳ#PMao?>g!]yP*܅ogo":^d"4<7G#H/δ[ nڷb`C)қi͹s%O$+hw(O;#e: @QYtqAZw,޵sm(lAq~=;tЬ7C#t8=;AP-o%]L A:.Ì]a(wpJ;= H6:6al'2%c@F_8k3ӉJsDeX6y-drwuiًWgLO#g11u E(]b ݁ #W>KAF;)WKC[a嬫(d Q`sqbLA}`x:m΄8wЉ4vydh&3*Q52+<-,ivyo_?@ghWõCVd~J\v>;؉ 3uD^}7QoǮčayV8t<^Bq={:j'&i6Pl6Y׃EOՌ5'EP&tYZU^p}z0Gy@HPjOn]ɽC4w=e+=6_h:Н\dD rv@ )aهv}cϹlLȏiW/=9T%*Pc7mWj>_oQ/Ùɴ@`8BLGt.!mc*޶e۲ߵuR3o{FؐȆEE=nS}쳤;]1GU2߹#smQ"h)ɟ}2:_9U#:|Áh_"V4:/w7; Ԡ~mU5=5UQY96Ku<6o+ SGͶtvPX bWDUa;ShO a+",Wl= 7aq Qnv(T8:9* 9__b[vWXajA ?،#Z/R%7) ߾{o>f£_*bmg:QFs!Jޗ;E`n$q^.Ηkл[PU+y0Ȇ 2¤5P[l=,k[-&ETX_9 uw9j}rS^#u풷asSHq=;_Nl((̈́1KxYI.&9{k4CY1Ү(,6|qO+bZ. 1͚j2'AmGћs3QB{hȐB kl)?d,hz3`ebbkV فḽ>tD*|WyqU1OFqR"Z۴^~lՊ~:5z:UU;;93ZS:; QMuerm,ZlyQY+",vK=IwjH_ϊHZj+LM]T*x3HNo6FrR- lO n'Ezvzea%Xp(h